Combined with the findings that (1) SLNCR1, but not SLNCR2 or SLNCR3, increases melanoma invasion (Figure S1) and (2) knockdown of SLNCR1, but not SLNCR, significantly decreases MMP9 (Table S1; data not shown), we conclude that SLNCR isoforms uniquely regulate melanoma invasion. The gene discussed is MMP9; the disease is melanoma.