Taken together, these results demonstrate that loss of CKII phosphorylation of HPV-18 E7 in cells derived from a cervical cancer, has diverse inhibitory effects upon the ability of the cells to proliferate and to invade a collagen matrix, and the defect in the ability to invade is at least in part due to downregulation of MMP1/13. This evidence concerns the gene MMP1 and cervical carcinoma.