Furthermore, we found increased FPR1/FPR2 ratio and insufficiency of FPR2 and FPR3 in the OSA patients with EDS and hypertension phenotypes, respectively, while long-term CPAP treatment decreased FPR1 expression and FPR1/FPR2 expression ratio, and increased FPR3 and FPR2 expression. The gene discussed is FPR2; the disease is Ehlers-Danlos syndrome.