We have found a link of FPR1 over-expression and FPR2 under-expression on blood neutrophil along with defective production of LXA4/RvD1, as well as FPR3 insufficiency of M1 monocyte, M2a monocyte, and NK cell, to OSA and its adverse consequences, including hypertension and EDS. Here, FPR3 is linked to Ehlers-Danlos syndrome.