Expression studies, besides confirming IRS‐1 down‐regulation in miR‐126‐transduced A375M melanoma compared with TripZ control cells, showed the strong induction of IRS‐1 in PIK‐75 + vemurafenib cotreated A375M cells, a result suggestive of the association of its activation with drug resistance. Here, IRS1 is linked to melanoma.