These two flavonoids were shown to initiate apoptosis through activation of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) (a substrate of activated caspase-3) as well as downregulating oncogenic proteins, such as inducible nitric oxide (iNOS), cyclooxygenase (COX-2), myeloid cell leukemia-1 (Mcl-1), and K-ras in human lung carcinoma H1299 cells [34]. The gene discussed is CASP3; the disease is lung carcinoma.