AKT1 and Hyperglycemia: Diallyl trisulfide (DATS) is a garlic-derived organosulfur compound that possesses a variety of well-documented pharmacological activities, including cardiovascular protective effects through inhibition of hyperglycemia-induced vascular endothelial injury, attenuation of mitochondrial oxidative stress, and prevention of hyperglycemia-induced cardiac apoptosis; at the gene level, DATS has been shown to activate the insulin-like growth factor 1 receptor/p-protein kinase B (Akt) signaling pathway and to regulate the expression of ROS-generating enzymes [15, 16].