Additionally, entities previously falling into a “Burkitt-like” lymphoma category (i.e., aggressive B cell lymphoma entities resembling BL) are classified into either high-grade B cell lymphoma with MYC and BCL-2 and/or BCL-6 rearrangement, Burkitt-like lymphoma with 11q aberration, or high-grade B cell lymphoma, not otherwise specified. The gene discussed is MYC; the disease is lymphoma.