SBDS and Shwachman-Diamond syndrome: Release of eIF6 in the cytoplasm is catalysed by EFL1 (elongation factor like GTPase 1, an EF-2 homolog) and its cofactor SBDS (Shwachman-Bodian-Diamond syndrome, yeast Sdo1) (Bécam et al., 2001; Senger et al., 2001; Menne et al., 2007; Finch et al., 2011; Wong et al., 2011; Weis et al., 2015).