Mutations in the GLI3 gene (MIM 165240) have been associated with five diverse disorders including the Greig cephalopolysyndactyly syndrome (GCPS; MIM 175700), Pallister–Hall syndrome (PHS; MIM 146510), and Acrocallosal syndrome (ACLS; MIM 200990), postaxial polydactyly type A/B (PAP‐A/B; MIM 174200) and preaxial polydactyly type‐IV (PPD‐IV; MIM 174700), and somatic hypothalamic hamartomas (MIM 241800). This evidence concerns the gene GLI3 and Pallister-Hall syndrome.