RRM1 and lung carcinoma: In the lung cancer study, in the summary of all 84 nCounter normalization options (Supplementary Figure S3), NNN and some other options have reasonable narrow TRA plots and reasonable (RRM1, ERCC1) correlation close to that of the RUV-III normalization, but RLE plots for these options include many boxes far from centered (blue), while with RUV-III they are all centered (Figure 1A, and extreme right of Supplementary Figure S3).