LEP and type 2 diabetes mellitus: Inhibition of EGFR and downstream signaling cascades, most notably in vulva carcinoma Induction of cancer cell apoptosis, reduced oxidative damage to DNA, inhibited cell growth and decreased cancer cell proliferation, notably in leukemia, lung, colon, skin and prostate cancer Prevention of Type II Diabetes through enhanced adiponectin and leptin secretion Preventative effect on Type II Diabetes through increased phosphorylation of AMPKα at Thr172 in rat adipose cells