ABCB1 is recognized as a potential target gene of high risk of IBD, colorectal cancer (CRC), Crohn's disease and ulcerative colitis (Onnie et al., 2010; Senhaji et al., 2015), ABCB1 may regulate functions of transporter activity, ATPase activity and transmembrane movement of substances in the immune response through ABC transporters signaling pathway during infection. Here, ABCG2 is linked to Crohn disease.