ABCB1 and colorectal cancer: ABCB1 is recognized as a potential target gene of high risk of IBD, colorectal cancer (CRC), Crohn's disease and ulcerative colitis (Onnie et al., 2010; Senhaji et al., 2015), ABCB1 may regulate functions of transporter activity, ATPase activity and transmembrane movement of substances in the immune response through ABC transporters signaling pathway during infection.