Accordingly, mutations present in genes of the TLR3 signaling pathway, such as the gene encoding for TANK-binding kinase 1 (TBK1), correlated with the development of herpes simplex encephalitis (HSE) in children and young adults (Herman et al., 2012; Lim et al., 2014). This evidence concerns the gene TLR3 and herpes simplex encephalitis.