Type-I IFNs are a broad family of molecules that can be secreted by numerous cell types early after infection in response to pathogens such as viruses, with some well-known members being IFN-α, IFN-β, and IFN-ε, and others more recently described IFN-υ, IFN-ω, and IFN-ζ (Hemmi et al., 2002; Al-Khatib et al., 2004; Diebold et al., 2004; Oritani and Tomiyama, 2004; Theofilopoulos et al., 2005; Ma et al., 2018). This evidence concerns the gene IFNB1 and infection.