Although some level of interference has been described by HSVs over the nucleic acid sensors described above, the DNA sensor termed DNA-dependent activator of interferon (DAI), which is expressed in primary vaginal tissue has been reported to readily detect HSV-2 and lead to IL-6 and IFN-β release upon infection (Triantafilou et al., 2014). The gene discussed is IFNB1; the disease is infection.