Furthermore, the ratio of neutrophils (i.e., CD45+Ly6G+ cells per gram of tumor) to T lymphocytes (defined as the sum of CD45+CD4+ and CD45+CD8+ per gram of tumor) tended to be lower in the tumors of mice treated with the combination of TAB004 + Lip-MSA-IL-2 compared to tumors from mice treated with the vehicle (PBS), and was lower than the neutrophil/T lymphocyte ratio in tumors from mice treated with Lip-MSA-IL-2 (p < 0.05; Figure 8B). Here, CD4 is linked to neoplasm.