Interestingly, the blood neutrophil/lymphocyte ratio, an independent prognostic marker of tumor progression (i.e., the lower the blood neutrophil/lymphocyte ratio, the better the outcome (65, 66), was determined to be lower in mice treated with TAB004 alone or with the combination of TAB004 + Lip-MSA-IL-2. This evidence concerns the gene IL2 and neoplasm.