For this aim, tumour cell and MSC co-cultures can be admixed to high biocompatible scaffolds of natural origin (i.g. collagen, hyaluronan, matrigel, elastin), or synthetic origin (polyethylenglycol, polyvinvyl alcohol, ceramics, or biomaterials), or also ECM isolated from tumour biopsies to mimic microenvironmental conditions (42). Here, ELN is linked to neoplasm.