Conversely, MSC produce a plethora of cytokines which, in turn, modulates cancer cell behaviour: IL-6 and IL-8 that promote tumour cell proliferation, survival, migration, and invasion of different tumour cells (26, 88–90), CCL5 that support metastasis in several cancers (52, 91–93), the pro-angiogenic cytokine VEGF that enhances tumour growth and metastasis (94, 95), and TGF-β that fosters tumour invasion and metastasis via EMT (96). This evidence concerns the gene IL6 and cancer.