ACE and Renal insufficiency: Similarly, Zucchelli et al. [35] in their prospective, randomized controlled trial showed the influence of captopril (an ACE inhibitor) and nifedipine (a CCB) on BP, renal insufficiency progression and proteinuria for three consecutive years found that both treatments exhibited similar effects on the progression rate of renal failure with similar reduction in BP seen with no significant reduction in proteinuria.