Since TJ disruption is considered a vital event in the pathogenesis of intestinal inflammation, and there is increased permeability of the small intestine both in CF humans and in CF mice (Cftr knockout mouse mode) [20], we explored the physiological functions of P131R-SLC26A3 on the TJ protein ZO-1 and CFTR. Here, TJP1 is linked to cystic fibrosis.