Similarly, with regard to the immunophenotypic expression of UCP1 noted in some leiomyosarcomas, there is evidence from ribosomal profiling that a subset of beige fat cells are of smooth muscle-like origin; it has also previously been reported that UCP1 mRNA is expressed in uterine smooth muscle cells [11, 13]. Here, UCP1 is linked to leiomyosarcoma.