Enhanced activation of transposable elements is associated with a response to environmental change and as well as with syndromes caused by MeCP2 (methyl-CpG binding protein 2; involved in transcription regulation) and ATM (ataxia telangiectasia, mutated; involved in DNA repair machinery) mutations (Bundo et al., 2014). Here, MECP2 is linked to Ataxia-telangiectasia.