Treatment of primary GECs from periodontitis patients with I-BET151 prior to P. gingivalis infection resulted in significant suppression of IL6, IL1B, CCL2, and COX2. However, in contrast to TIGKs, IL8, and CXCL10 mRNA levels were not affected by BET inhibition, whereas CCL20 expression was consistently induced (Figure 6C). Here, IL1B is linked to periodontitis.