Peripheral blood levels of the IFNγ-related chemokines CXCL9 and CXCL10 also correlated to disease activity measures, such as clinical scores, the modified Localized scleroderma skin severity index (mLoSSI), and the Physician Global Assessment of disease activity (66, 67, 78) (Table 1), underscoring their potential as serological biomarkers of disease activity. This evidence concerns the gene IFNG and scleroderma.