In adult SSc, IL-13+, and not IFNγ+, CD8+CCR10+ cells appear to be the skin homing cell type that propagates disease (81), emphasizing possible biological differences in scleroderma phenotypes: a more inflammatory, TH1/TC1 phenotype in LS and a more fibrotic, TH2/TC2 phenotype in SSc. This evidence concerns the gene IL13 and systemic sclerosis.