Studies have identified V. cholerae O141 and O75 harboring the CTX prophage including the ctxA gene which have been responsible for cholera-like outbreaks, e.g., in the United States (Dalsgaard et al., 2001; Crump et al., 2003; Haley et al., 2014). The gene discussed is CYP27A1; the disease is vibrio infectious disease.