CXCL8 and clostridium difficile infection: Analysis of the basolateral compartment supernatant for the host chemokine IL-8, which has been previously implicated in CDI (Rao et al., 2014), revealed that IL-8 levels were low at 6 h p.i. but increased at 24 and 48 h p.i. in this infection model compared to uninfected controls (Figure 3C).