Acetylcholinesterase (AChE) inhibitors e.g., galantamine, rivastigmine, donepezil hydrochloride, which produces side effects like, bronchoconstriction and hypotension and NMDA (N-methyl-D-aspartate) receptor antagonist e.g., memantine produces side-effects like, nausea, vomiting, and diarrhea.(16, 17) So, there is an urgent need for development of new drugs for treatment or management of AD. The gene discussed is ACHE; the disease is Alzheimer disease.