Deposition of amyloid beta, hyperphosphorylation of tau protein (52, 56), increase in AChE activity (5), imbalance in level of neurotransmitters, inflammatory cytokines (12), memory and learning deficits (57) are important manifestations caused due to aluminum neurotoxicity, which is involved in the etiology of AD (58). The gene discussed is MAPT; the disease is Alzheimer disease.