INS and metabolic syndrome: Although an augmentation in diastolic [Ca2+]i might participate in the impairment of the relaxation speed in MetS cells, previous reports in related insulin resistant models showed no changes in basal Ca2+ in cardiac cells (Dutta et al., 2001; Hintz et al., 2003), which is consistent with the decreased spark-mediated Ca2+ leak observed in our MetS model.