RYR2 and metabolic syndrome: Moreover, depressed cell shortening and slower cytosolic Ca2+ clearing have been documented in cardiomyocytes of the prediabetic sucrose-fed rat model at early stages of MetS development (6–18 weeks of sucrose treatment) (Dutta et al., 2001; Hintz and Ren, 2002; Davidoff et al., 2004; Wold et al., 2005; Vasanji et al., 2006; Balderas-Villalobos et al., 2013; Okatan et al., 2016), but the participation of the RyR2 has not been fully elucidated.