STAT3 and Duchenne muscular dystrophy: Then, a permanent knockout of STAT3 and a direct and long-term treatment with STAT3 inhibitors, which causes a gradual depletion of MuSCs, might have adverse effects on MuSCs and regeneration in DMD patients (Zhu et al., 2016), in contrast with other approaches such as transient inhibition by chemical inhibitors or siRNA, shown elsewhere (Price et al., 2014; Tierney et al., 2014).