Accordingly, our transcriptomic analysis in 3 different cohorts from published database indicates that SGMS1 was downregulated in primary and metastatic human melanoma as compared to normal skin and nevus (Figure 1C; Haqq et al., 2005; Talantov et al., 2005; Riker et al., 2008). This evidence concerns the gene SGMS1 and melanoma.