Used up of USP7 significantly restrained the proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells in vitro and in vivo, accompanied by downregulation of the NOTCH1 protein level, suggesting that targeting the USP7/NOTCH1 axis is a novel strategy to combat T-ALL and other NOTCH1-related malignancies (Figure 7C) (Shan et al., 2018). This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.