According to a research in 2017, β-catenin can be deubiquitinated and stabilized by USP7 in adenomatous polyposis coli (APC) truncating mutated colorectal cancer (CRC) but not APC wide type CRC, which resulting in the activation of Wnt pathway (Novellasdemunt et al., 2017). The gene discussed is USP7; the disease is colorectal carcinoma.