In recent years, many plant components, Ocimum gratissimum extract (Shaw et al., 2017), mango leaf Extract (Ronchi et al., 2015), Carica papaya extract (Brasil et al., 2014), and mulberry leaf aqueous extract (Yang et al., 2012), had shown anti-hypertension effects through an inhibition of ACE activity. The gene discussed is ACE; the disease is Hypertension.