In addition to the role of ADAM10 in AD, recent studies suggest that ADAM10 may contribute to other neurological diseases including fragile X syndrome, traumatic brain injury, and psychiatric disorders (Warren et al., 2012; Pasciuto et al., 2015; Zilhao et al., 2015; Del Turco et al., 2016). This evidence concerns the gene ADAM10 and fragile X syndrome.