CDKL5 and craniodiaphyseal dysplasia: Cdkl5 KO mice recapitulate different features of CDD, exhibiting severe impairment in learning and memory, visual and respiratory deficits, and motor stereotypies (Wang et al., 2012; Amendola et al., 2014; Fuchs et al., 2014, 2015; Mazziotti et al., 2017).