Proper gene dosage of UBE3A is crucial to normal brain development, as evidenced by the neurodevelopmental disorders associated with deletions, mutations, and copy number variations (CNVs) of UBE3A. Angelman syndrome (AS) was characterized behaviorally by Harry Angelman to consist of “puppet”-like behavior, a distinctive feature of AS (Angelman, 1965). The gene discussed is UBE3A; the disease is Angelman syndrome.