Buspirone and other 5-HT1A receptor partial agonists and antagonists are also reported to enhance the therapeutic effects of antidepressants (Blier and Ward, 2003), as seen in the Sequenced Treatment Alternatives to Relieve Depression (STAR∗D) study (Trivedi et al., 2006a) (Figure 1). The gene discussed is HTR1A; the disease is depressive disorder.