NR4A1 and breast cancer: LVI is a biomarker for aggressive BC and is considered predictive for metastasis.20 In other cancer types, gene sets associated with vascular invasion have been previously described, for example in hepatocellular carcinoma21 and endometrial cancer.22 Mannelqvist et al.23 suggested that an 18-gene set associated with vascular invasion in endometrial cancer22 was consistently associated with hormone receptor negativity, HER2 positivity, basal-like phenotype, reduced patient survival in BC patients.