We analysed murine tumours driven by MYC alone.32 Out of 21 metabolic genes for 13 genes involved in the Krebs cycle, one carbon metabolism and nucleotide and glutathione biosynthesis, the co-expression of MYC and N1ICD led to the overexpression that was not significant in the MYC-only tumours and for 3 genes it enhanced the over-expression that was less pronounced in the MYC-only tumours (Fig. 6a). Here, MYC is linked to neoplasm.