COMT and breast cancer: Moreover, according to recent metabolomics studies, i.e. in a first study investigating metabolic profiles of smokers and non-smokers with BC outcome26, catechol-O-methyltransferase (COMT), iodotyrosine deiodinase (IYD), tubulin tyrosine ligase (TTL) were correlated with BC survival, while in a study investigating population-based metabolic differences associated with BC27, high expression of lysine demethylase 2A (KDM2A) and prolyl 3‐hydroxylase 2 (P3H2) and low expression of mitochondrial malic enzyme 3 (ME3) was correlated with poor survival of African American BC patients.