IL27 and HIV infectious disease: In the context of an HIV infection, a positive correlation was reported between the levels of IL-27 in the plasma and of proviral DNA in peripheral blood mononuclear cells,68 whereas it has been shown that IL-27 inhibits the in vitro HIV infection.69,70 Furthermore, other groups as well as ours have previously reported a defect in the expression of mRNAs encoding for p40 and p35 of IL-12.2,71 However, the impact of IL-27 on the differentiation of Tfh cells derived from MLNs, in the context of SIV infection, is unknown.