BACE1 and Alzheimer disease: Likewise, decreased DNA methylation across DSCAML1 intron 3 (average of 22 CpGs) correlated with elevated BACE1 mRNA expression in early AD (p < 0.001, robust linear regression model) and a rapid progression of cognitive symptoms (decline in perceptual speed; p < 0.05, linear mixed model; Supplementary Fig. 10).