In fact, DSCAML1 intron 3 contained the highest concentration of DNA methylation abnormalities in AD neurons affecting a total of 16 enhancers with cumulatively 304 significantly disrupted CpG/CpH sites in this 235.7 kb genomic area (0.62%–5.25% hypomethylation in AD; q < 0.05 to 10−14, robust linear regression model followed by hypergeometric test; Fig. 1d). This evidence concerns the gene DSCAML1 and Alzheimer disease.