Most notably, DSCAML1 intron 3 contained 5 enhancers showing DNA hypomethylation occurring early in AD (0.70 ± 0.12% hypomethylation in AD; q < 0.05, robust linear regression model and hypergeometric test; Fig. 1d and Supplementary Fig. 5). This evidence concerns the gene DSCAML1 and Alzheimer disease.