One of the most significantly disrupted regulatory elements in AD neurons was an enhancer located in intron 3 of the DSCAML1 gene (chr11: 117,504,514–117,506,898; 1.56% hypomethylation in AD; q < 10−14, robust linear regression model followed by hypergeometric test; Fig. 1d, e). The gene discussed is DSCAML1; the disease is Alzheimer disease.