As the immunohistochemical results shown in Fig. 2d, the results in Fig. 2d was quantified and statistical analyzed (Supplementary Table), we found that the protein levels of TFAP2B and COX-2 were significantly higher in thyroid cancer tissues than in the adjacent tissues, as well as western blot results (Fig. 2e), and the relative protein level is shown in Supplementary Fig. A. This evidence concerns the gene PTGS2 and thyroid cancer.