VEGFA and lung adenocarcinoma: Previous studies showed that TFAP2B was demonstrated to be highly expressed in human lung adenocarcinoma and it was positively correlated with the poor prognoses of lung adenocarcinomas (P < 0.001), knockdown of TFAP2B inhibited cell growth and induced apoptosis in lung adenocarcinoma cells in vitro and in a lung cancer subcutaneous xenograft model by simultaneously regulating multiple signaling pathways, such as the ERK/p38, VEGF/PEDF, and caspase-dependent pathways20.