Interestingly, a negative correlation was further observed between visceral Sirt6 expression and fasting blood sugar (FBS) or hemoglobin A1c (HbA1c) levels, suggesting that low Sirt6 expression is likely to be associated with hyperglycemia as well as visceral obesity in individuals with type 2 diabetes. The gene discussed is SIRT6; the disease is type 2 diabetes mellitus.