In the present study, we investigated the interaction of FGFR2 polymorphisms in the onset of osteoporosis through linkage disequilibrium analysis and the results showed the strong linkage disequilibrium among FGFR2 rs2981582, rs2420946, rs1219648 and rs2981579 polymorphisms. The gene discussed is FGFR2; the disease is osteoporosis.