Pooled analyses showed that LEP rs7799039 G/A variant was significantly associated with CAD under over-dominant model (GA vs. GG + AA, P=0.0007, OR = 1.36, 95%CI: 1.14–1.63, I2 = 41%, FEM) in overall population, and this significant finding was further confirmed in East Asians in subsequent subgroup analyses (GA vs. GG + AA, P=0.04, OR = 1.50, 95%CI: 1.02–2.20, I2 = 59%, REM). Here, LEP is linked to coronary artery disorder.