This data suggests that the combination of Lm-ANXA2 and anti-PD-1 blockade treatment induced an ANXA2-specific T cell response in the tumor microenvironment of PDACs and indirectly suggests that the ANXA2-expressing Listeria can induce the production of IFNγ-expressing CD8+ T cell infiltration in PDACs in presence of anti-PD-1 antibody. The gene discussed is CD8A; the disease is neoplasm.