In addition, it was found that Cyr61 could not only stimulate IL-6 production by FLS via the Cyr61/αvβ5/Akt/NF-κB signaling pathway [8], but also promote neutrophil infiltration via upregulation of IL-8 production in RA-FLS [9]. The gene discussed is NFKB1; the disease is rheumatoid arthritis.