Further data supporting a link between PTGS2 and macrophages were found in one of the four datasets investigated (GSE76039); in this series, the authors established an M2 score indicative of macrophage infiltration based on a gene signature overexpressed in M2 macrophages, and reported a high M2 score in ATCs [35]. The gene discussed is PTGS2; the disease is Ehlers-Danlos syndrome, musculocontractural type.