Phenotype analysis showed that macrophages differentiated in the presence of CM derived from the four thyroid tumor cell lines (Tumor cells-Conditioned macrophages, TuC-Macro), expressed low MHC II molecules and higher CD206 compared with macrophages exposed to Nthy-derived CM (Fig. 2c, top panel); this indicates that they display an M2-like phenotype. Here, MRC1 is linked to thyroid tumor.