Wee et al. reported that EZH2 directly repressed the expression of interferon-gamma receptor 1 (IFNGR1) to inhibiting activation of IFN-JAK-STAT1 tumor-suppressor signaling and apoptosis in a MYC-dependent manner in a subset of metastatic prostate cancers [36]. The gene discussed is IFNGR1; the disease is neoplasm.