With findings supporting the regulation of the biological activity of A549-SP+ via the TGF-β pathway due to lncRNA MBNL1-AS1 and miR-301b-3p via the TGF-β pathway, our last objective was to evaluate whether the restored lncRNA MBNL1-AS1 or depleted miR-301b-3p affected the xenograft tumor formation in nude mice. Here, MBNL1 is linked to neoplasm.