Pancreatic tumors in patients are well known for their ability to exclude T cells (30–32), and limited T cell infiltration is also a prominent feature of pancreatic tumors in KrasLSL–G12D/+ Trp53LSL–R172H/+ Pdx1-Cre mice (30, 33, 34). The gene discussed is PDX1; the disease is pancreatic neoplasm.