This is in part due to limited levels of ctDNA and is highly dependent on the method used for mutational analysis.18, 19 Given these considerations, the objective of the present study was to assess the utility of detecting mutations in ctDNA and in mimicking circulating tumor cells (mCTCs) using the digital PCR OncoBEAMTM‐EGFR assay compared to NGS‐56G to detect the p.T790M EGFR mutation in paired samples. The gene discussed is EGFR; the disease is neoplasm.