Moreover, forskolin inhibited mTORC1 activity not only in HEK293A and MEF cells, but also in human prostate cancer cells (PC3 and LNcap/AR), human non-small cell lung carcinoma cells (H1299 and H1944), breast cancer cells (MDA-MB-231), haploid cells (HAP1) derived from chronic myelogenous leukemia cells (KBM-7), monkey kidney fibroblasts-like cells (COS7), human cervical cancer derived cells (HeLa), and human pancreatic cancer cells (MIA Paca-2 and PANC-1) (Figure 1E). The gene discussed is AR; the disease is familial pancreatic carcinoma.